The research conducted in our laboratory lies at the interface of engineering, materials science, and life sciences. Our research focus is based on utilization of polymer science and micro/nanofabrication techniques to generate functional (bio)materials and surfaces.
NEWS- April, 2016
Erhan's article entitled Encapsulated Hydrogels by E-Beam Lithography and Their Use in Enzyme Cascade Reactions has been accepted for publication in Langmuir.
Electron beam (e-beam) lithography was employed to prepare one protein immobilized hydrogel encapsulated inside another by first fabricating protein-reactive hydrogels of orthogonal reactivity and subsequently conjugating the biomolecules. Exposure of thin films of eight arm star poly(ethylene glycol) (PEG) functionalized with biotin (Biotin-PEG), alkyne (Alkyne-PEG) or aminooxy (AO-PEG) end-groups to e-beam radiation resulted in cross-linked hydrogels with the respective functionality.
NEWS- December, 2015
Erhan's article entitled "Direct Write Protein Patterns for Multiplexed Cytokine Detection from Live Cells Using Electron Beam Lithography" has been accepted for publication in ACS nano.
A multiplexed cytokine immunoassay utilizing electron beam lithography and a trehalose glycopolymer as a resist for the direct writing of antibodies on silicon substrates, allowing for micro- and nanoscale precision of protein immobilization.
NEWS- July, 2015
Erhan Bat received TÜBİTAK 3501 National Young Resercher Career Development Grant for his project entitled "Production of Graphene Oxide and Polymer Based Nanocomposite Membranes via Breath Figure Method".
In the proposed research breath figure method will be used to produce two different graphene oxide-polymer based nanocomposite membranes: one for gas separation and one having microsieve structure. Within the scope of the project, the process parameters for obtaining porous polymers will be optimized and the assessment of the suitability obtained membranes for separation processes will be performed.
NEWS- June, 2015
Erhan's article entitled "Imine Hydrogels with Tunable Degradability for Tissue Engineering"
has been accepted for publication in Biomacromolecules.
Hydrogels containing adipohydrazide-functionalized PEG (PEG-ADH) and PEG-CHO were found to degrade more rapidly than gels formed from carbodihydrazide-functionalized PEG (PEG-CDH).
Erhan's article entitled “Trehalose Glycopolymer Resists Allow Direct Writing of Protein Patterns by Electron-Beam Lithography”
has beeen accepted for publication in Nature Communications.
I, spin coating with poly(SET)-protein-1 solution and writing of the first layer. II, rinsing of the unexposed poly(SET)-protein-1 followed by spin coating poly(SET)-protein-2, alignment to the first layer and writing of the second layer. III–IV, multiple protein patterns are obtained by repeated spin coating, alignment, writing and rinsing steps. All of the steps including EBL were performed outside the cleanroom. Protein structure from PDB# 1W4Y.
NEWS- February, 2015
METU 2015 Research Capacity Improvement Grant was recieved by Erhan Bat for his project entitled "Various Lithographic Techniques and Their Biomedical Applications".
The grant will be used to install a nanoimprint lithography system within a class 100 hood together with the auxillary units such as an oxygen plasma chamber and a spin-coater. Nanoimprint lithography is a method of fabricating patterns down to 10 nm scale. The system to be installed will be capable of performing ultraviolet and thermal nanoimprint lithography. Therefore, this nanofabrication tool is expected to be utilized by METU faculty working on a broad range of areas such as membranes, microreactors, microfluidics, biomaterials, photonics, solar cells, and biosensors.