Relevant Publications:
1. Cevheroğlu O, Becker JM, Son ÇD. GPCR-Gα protein precoupling: Interaction between Ste2p, a yeast GPCR, and Gpa1p, its Gα protein, is formed before ligand binding via the Ste2p C-terminal domain and the Gpa1p N-terminal domain. Biochim Biophys Acta (2017), pii: S0005-2736(17)30304-82. Cevheroğlu O, Kumaş G, Hauser M, Becker JM, Son ÇD. The yeast Ste2p G protein-coupled receptor dimerizes on the cell plasma membrane. Biochim Biophys Acta (2017), May;1859(5):698-711
3. Sahin ME, Can T, Son CD. GPCRsort-responding to the next generation sequencing data challenge: prediction of G protein-coupled receptor classes using only structural region lengths. OMICS. (2014) Oct;18(10):636-44
4. Srinivasan R, Pantoja R, Moss FJ, Mackey ED, Son CD, Miwa J, Lester HA. Nicotine up-regulates α4β2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning. J Gen Physiol (2011) Jan;137(1):59-79
5. Cagdas D. Son, Fraser J. Moss, Bruce N. Cohen, Henry A. Lester. Nicotine Normalizes Intracellular Subunit Stoichiometry of Nicotinic Receptors Carrying Mutations linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy. Molecular Pharmacology (2009) May;75(5):1137-48
6. Lester HA, Xiao C, Srinivasan R, Son CD, Miwa J, Pantoja R, Banghart MR, Dougherty DA, Goate AM, Wang JC. Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery. AAPS J. (2009) March; 11(1):167-77.
7. George K. E. Umanah, Cagdas Son, FaXiang Ding, Fred Naider and Jeffrey M. Becker. Cross-Linking of a DOPA-Containing Peptide Ligand into Its G Protein-Coupled Receptor. Biochemistry (2009) March; 48(9):2033-44.
8. Li-Yin Huang, George Umanah, Melinda Hauser, Cagdas Son, Boris Arshava, Fred Naider, and Jeffrey M. Becker. Unnatural amino acid replacement in a yeast G protein-coupled receptor in its native environment. Biochemistry (2008) May; 47(20):5638-48.
9. Byung-Kwon Lee, Kyung-Sik Jung, Cagdas Son, Heejung Kim, Nathan C. VerBerkmoes, Boris Arshava, Fred Naider, and Jeffrey M. Becker. Affinity purification and Characterization of a G-Protein Coupled Receptor, Saccharomyces cerevisiae Ste2p.Protein Expression and Purification (2007) Nov; 56(1):62-71.
10. Cagdas D. Son, Hasmik Sargsyan, Hurst GB, Fred Naider, Jeffrey M. Becker. Analysis of Ligand-Receptor Cross-linked Fragments by Mass Spectrometry. Journal of Peptide Research (2005) Mar; 65(3):418-26
11. Cagdas D. Son, Hasmik Sargsyan, Fred Naider, Jeffrey M. Becker. Identification of binding regions of the Saccharomyces cerevisiae alpha-factor pheromone receptor (Ste2p) by photo-affinity cross-linking. Biochemistry (2004) Oct 19; 43(41):13193-203
12. Andjelka Celic, Negin P. Martin, Cagdas D. Son, Jeffrey M. Becker, Fred Naider, and Mark E. Dumont.Sequences in the Intracellular Loops of the Yeast Pheromone Receptor Ste2p Required for G Protein Activation. Biochemistry (2003) Mar 18; 42(10):3004-17.
13. Lee BK, Lee YH, Hauser M, Son CD, Khare S, Naider F, Becker JM. Tyr266 in the sixth transmembrane domain of the yeast alpha-factor receptor plays key roles in receptor activation and ligand specificity.Biochemistry (2002) Nov 19; 41(46):13681-9.
14. L. Keith Henry, Sanjay Khare, Cagdas Son, Fred Naider and Jeffrey M. Becker. Identification of a contact region between the tridecapeptide alpha-factor mating pheromone of Saccharomyces cerevisiae and its G protein-coupled receptor by photo-affinity labeling. Biochemistry (May 2002) 14; 41(19):6128-39.