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UNDERGRADUATE GRANTS |
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Development of a Sensitive Analytical Method for
Arı, Betül Department of Chemistry Supervisor: Prof. Dr. O. Yavuz Ataman
Thallium is known as highly toxic element even more than the Cd, Hg, Pb, Cu and Zn which has many serious health effects on human health upon exposure in small amounts over a long time period. Although thallium is widely spread in the natural environment, it was found that its concentration is 0.001–0.25 mg/ L in groundwater, 0.001–0.036 mg/L in lake water, and 0.012–0.016 mg/L in seawater. In present, thallium has been used in electrical and electronics industries as in electronic devices for semiconductors, low temperature thermometers, and in mixed crystals for infrared instruments and laser equipment. For determination of thallium, there are several methods such as Graphite Furnace Atomic Absorption Spectrometry (GFAAS), Hydride Generation using in situ trapping in Graphite Tube by Atomic Absorption Spectrometry and Inductive Coupled Plasma Mass Spectroscopy (ICP-MS). In this study, four different methods are to be developed which have sufficient sensitivity and lower cost. The detection limit and characteristic concentration for method A were found as 1.70 mg/L, and 0.97 mg/L, respectively, whereas in Method B, the values were found as 0.41 mg/L and 0.67 mg/L, respectively.
Characterization of Ambroxol and Its Protecting Materials in Different Types of Syrups
Yıldıran, Ahmet Department of Chemistry Education Supervisor: Prof. Dr. O. Yavuz Ataman
A rapid and accurate high-performance liquid chromatographic method is described for the simultaneous determination of ambroxol, methyl paraben and propyl paraben in syrups. The method separates ambroxol from methyl- and propyl paraben and from other multi-component mixtures. Chromatographic separation was achieved on a Dionex C18 column (150mm x 4.6mm, 5μm). The mobile phase consisting of a mixture of acetonitrile, methanol and 0.5% ammonium acetate (39:11:50, (v/v/v), pH 5.5) was delivered at a flow rate of 1.0 mL/min. Detection was performed at 245 nm. Separation was completed in approximately 10 minutes.
Determination of Lead in Anatolian Spices Using HG—AAS
Eroğlu, Şefika Department of Chemistry Supervisor: Prof. Dr. O. Yavuz Ataman
It is known that lead is a health-endangering metal for humans; its effects include blood enzyme changes, anemia, hyperactivity and neurological disorders [1]. This element may enter the food chain because of their uptake by edible plants. Thus, determination of heavy metals in food and diet is very important. In literature, there have been many determination techniques such as Atomic Absorption Spectrometry (AAS), Electrothermal Atomic Absorption Spectrometry (ETAAS), Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for lead in different matrices [2-4]. The determination of lead requires sufficiently sensitive procedures for detection at the µg/l level. HG-AAS with W-coil trap has been applied for lead determination; the approach is essentially the same as the study reported for Bi [5]; parameters were optimized for Pb. Due to separation of analyte from sample matrix and pre-concentration, sensitivity is enhanced and interferences are reduced. The technique was applied to determination of lead in Anatolian spices most commonly consumed by people; namely, sage (1.78-1.80 µg/g), paprika (193-801 ng/g), thyme (205-1009 ng/g), lime tea (394-931 ng/g), peppermint (291-745 ng/g) and cummin (326-413 ng/g). In this method, limit of detection (LOD) and characteristic concentration (C0) for Pb were found to be 53 ng/L and 24 ng/L, respectively.
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